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Subnetworks conserved in human and mouse

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Mouse Subnetwork Human Subnetwork
G 1763 KPNB1 12785 RANBP1 1763--12785 10250 EXOSC2 1763--10250 4749 RANGAP1 1763--4749 1678 GART 1763--1678 3652 ABCE1 1763--3652 4703 KPNA6 1763--4703 3099 GFPT2 1763--3099 959 IPO5 1763--959 4420 ATIC 5195 PPAT 4420--5195 4420--1678 6161 SHMT1 4420--6161 14201 GCSH 4420--14201 12325 EXOSC5 12325--10250 15217 LSM5 12325--15217 12325--4703 12785--10250 12785--4749 12785--1678 12785--3652 12785--4703 12785--959 10250--3652 10250--4703 10250--959 5195--4749 5195--1678 5195--6161 5195--14201 1678--6161 1678--14201 1678--4703 1678--3099 1678--959 6161--15217 6161--14201 6161--4703 6161--3099 3652--959 4703--3099 4703--959 3099--959 G 1763 KPNB1 4420 ATIC 1763--4420 1678 GART 1763--1678 3652 ABCE1 1763--3652 4703 KPNA6 1763--4703 959 RANBP5 1763--959 12325 EXOSC5 4420--12325 12785 RANBP1 4420--12785 4420--1678 14201 GCSH 4420--14201 4420--3652 10250 EXOSC2 12325--10250 12325--1678 15217 LSM5 12325--15217 12785--15217 12785--14201 12785--3652 12785--959 5195 PPAT 5195--1678 5195--3652 4749 RANGAP1 1678--3652 6161 SHMT1 15217--14201 15217--3652 15217--959 14201--3652 3652--959 3099 GFPT2
Cytoscape file Cytoscape file

Confidence Information

Average fold change (normalized) 0.151163
Number of real subnetworks at this score 250
Number of random subnetworks at this score 10.60 +/- 3.92

Mouse genes' details

Gene Name Actual fold change Normalized fold change
KPNB1 1.15 0.16
ATIC 1.40 0.27
EXOSC5 1.60 0.32
RANBP1 1.11 0.26
EXOSC2 1.47 0.16
PPAT 1.49 0.20
RANGAP1 1.24 0.27
GART 1.53 0.22
SHMT1 1.68 0.08
LSM5 1.41 0.16
GCSH 1.16 0.14
ABCE1 1.53 0.14
KPNA6 1.19 0
GFPT2 1.79 0.29
IPO5 1.15 0.11

Human genes' details

Gene Name Absolute fold change Normalized fold change
KPNB1karyopherin (importin) beta 1 1.43 0.16
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 1.85 0.27
EXOSC5xosome component 5 2.07 0.32
RANBP1RAN binding protein 1 1.83 0.26
EXOSC2xosome component 2 1.46 0.16
PPATphosphoribosyl pyrophosphate amidotransferase 1.58 0.20
RANGAP1Ran GTPase activating protein 1 1.86 0.27
GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1.67 0.22
SHMT1rine hydroxymethyltransferase 1 (soluble) 1.20 0.08
LSM5LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.43 0.16
GCSHglycine cleavage system protein H (aminomethyl carrier) 1.38 0.14
ABCE1ATP-binding cassette, sub-family E (OABP), member 1 1.40 0.14
KPNA6karyopherin alpha 6 (importin alpha 7) 0 0
GFPT2glutamine-fructose-6-phosphate transaminase 2 1.96 0.29
RANBP5mportin 5 1.29 0.11

Go Enrichment

Mouse GO Terms Human GO Terms
GO:0006188 IMP biosynthetic process 2.82e-04 2 13 3 14467 GART,ATIC
GO:0046040 IMP metabolic process 2.82e-04 2 13 3 14467 GART,ATIC
GO:0006606 protein import into nucleus 2.62e-03 3 13 62 14467 KPNA6,KPNB1,IPO5
GO:0051170 nuclear import 2.75e-03 3 13 63 14467 KPNA6,KPNB1,IPO5
GO:0006544 glycine metabolic process 3.37e-03 2 13 9 14467 SHMT1,GCSH
GO:0017038 protein import 4.28e-03 3 13 73 14467 KPNA6,KPNB1,IPO5
GO:0009127 purine nucleoside monophosphate biosynthetic process 6.17e-03 2 13 12 14467 GART,ATIC
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 6.17e-03 2 13 12 14467 GART,ATIC
GO:0009126 purine nucleoside monophosphate metabolic process 8.50e-03 2 13 14 14467 GART,ATIC
GO:0009167 purine ribonucleoside monophosphate metabolic process 8.50e-03 2 13 14 14467 GART,ATIC
GO:0000059 protein import into nucleus, docking 9.80e-03 2 13 15 14467 KPNB1,IPO5
GO:0006913 nucleocytoplasmic transport 1.00e-02 3 13 97 14467 KPNA6,KPNB1,IPO5
GO:0051169 nuclear transport 1.03e-02 3 13 98 14467 KPNA6,KPNB1,IPO5
GO:0009156 ribonucleoside monophosphate biosynthetic process 1.12e-02 2 13 16 14467 GART,ATIC
GO:0009124 nucleoside monophosphate biosynthetic process 1.43e-02 2 13 18 14467 GART,ATIC
GO:0009161 ribonucleoside monophosphate metabolic process 1.43e-02 2 13 18 14467 GART,ATIC
GO:0009069 serine family amino acid metabolic process 1.59e-02 2 13 19 14467 SHMT1,GCSH
GO:0009123 nucleoside monophosphate metabolic process 1.77e-02 2 13 20 14467 GART,ATIC
GO:0006605 protein targeting 2.13e-02 3 13 125 14467 KPNA6,KPNB1,IPO5		 GO:0009113 purine base biosynthetic process 5.81e-06 3 14 11 21198 PPAT,GART,SHMT1
GO:0006144 purine base metabolic process 1.97e-05 3 14 16 21198 PPAT,GART,SHMT1
GO:0046112 nucleobase biosynthetic process 2.86e-05 3 14 18 21198 PPAT,GART,SHMT1
GO:0009112 nucleobase metabolic process 1.42e-04 3 14 30 21198 PPAT,GART,SHMT1
GO:0046148 pigment biosynthetic process 3.99e-04 3 14 42 21198 PPAT,GART,SHMT1
GO:0042440 pigment metabolic process 6.00e-04 3 14 48 21198 PPAT,GART,SHMT1
GO:0006188 IMP biosynthetic process 6.23e-04 2 14 5 21198 ATIC,GART
GO:0046040 IMP metabolic process 6.23e-04 2 14 5 21198 ATIC,GART
GO:0019748 secondary metabolic process 1.65e-03 3 14 67 21198 PPAT,GART,SHMT1
GO:0006607 NLS-bearing substrate import into nucleus 4.85e-03 2 14 13 21198 KPNB1,KPNA6
GO:0009071 serine family amino acid catabolic process 7.45e-03 2 14 16 21198 GCSH,SHMT1
GO:0046483 heterocycle metabolic process 7.71e-03 3 14 112 21198 PPAT,GART,SHMT1
GO:0006164 purine nucleotide biosynthetic process 8.57e-03 3 14 116 21198 PPAT,ATIC,GART
GO:0055086 nucleobase, nucleoside and nucleotide metabolic process 1.10e-02 4 14 360 21198 PPAT,ATIC,GART,SHMT1
GO:0006520 amino acid metabolic process 1.49e-02 4 14 389 21198 PPAT,GCSH,SHMT1,GFPT2
GO:0006163 purine nucleotide metabolic process 1.50e-02 3 14 140 21198 PPAT,ATIC,GART
GO:0006541 glutamine metabolic process 1.71e-02 2 14 24 21198 PPAT,GFPT2
GO:0006725 aromatic compound metabolic process 1.88e-02 3 14 151 21198 PPAT,GART,SHMT1
GO:0009127 purine nucleoside monophosphate biosynthetic process 2.01e-02 2 14 26 21198 ATIC,GART
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 2.01e-02 2 14 26 21198 ATIC,GART
GO:0009126 purine nucleoside monophosphate metabolic process 2.01e-02 2 14 26 21198 ATIC,GART
GO:0009167 purine ribonucleoside monophosphate metabolic process 2.01e-02 2 14 26 21198 ATIC,GART
GO:0006519 amino acid and derivative metabolic process 3.08e-02 4 14 470 21198 PPAT,GCSH,SHMT1,GFPT2
GO:0009156 ribonucleoside monophosphate biosynthetic process 3.46e-02 2 14 34 21198 ATIC,GART
GO:0009161 ribonucleoside monophosphate metabolic process 3.46e-02 2 14 34 21198 ATIC,GART
GO:0006544 glycine metabolic process 3.88e-02 2 14 36 21198 GCSH,SHMT1
GO:0009124 nucleoside monophosphate biosynthetic process 4.10e-02 2 14 37 21198 ATIC,GART
GO:0009123 nucleoside monophosphate metabolic process 4.10e-02 2 14 37 21198 ATIC,GART
GO:0009308 amine metabolic process 4.74e-02 4 14 526 21198 PPAT,GCSH,SHMT1,GFPT2