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Subnetworks conserved in human and mouse

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Mouse Subnetwork Human Subnetwork
G 5264 ZIC3 2484 SOX5 5264--2484 1251 GLI1 5264--1251 5532 ZIC1 5264--5532 8516 ALX3 5264--8516 2484--1251 2484--5532 2484--8516 1251--5532 1251--8516 5532--8516 G 5264 ZIC3 2484 SOX5 5264--2484 1251 GLI1 5264--1251 5532 ZIC1 5264--5532 8516 ALX3 5264--8516 2484--1251 2484--5532 2484--8516 1251--5532 1251--8516
Cytoscape file Cytoscape file

Confidence Information

Average fold change (normalized) 0.222705
Number of real subnetworks at this score 40
Number of random subnetworks at this score 0.80 +/- 0.96

Mouse genes' details

Gene Name Actual fold change Normalized fold change
ZIC3 3.44 0.50
SOX5 0.74 -0.35
GLI1 2.08 0.47
ZIC1 0.46 0
ALX3 0 0

Human genes' details

Gene Name Absolute fold change Normalized fold change
ZIC3Zic family member 3 (odd-paired homolog, Drosophila) 3.15 0.50
SOX5SRY (sex determining region Y)-box 5 0.45 -0.35
GLI1GLI family zinc finger 1 2.92 0.47
ZIC1Zic family member 1 (odd-paired homolog, Drosophila) 0 0
ALX3ALX homeobox 3 0 0

Go Enrichment

Mouse GO Terms Human GO Terms
GO:0007389 pattern specification process 8.55e-05 4 5 272 14467 ZIC1,ALX3,ZIC3,GLI1
GO:0048513 organ development 2.16e-03 5 5 1575 14467 ZIC1,SOX5,ALX3,ZIC3,GLI1
GO:0048731 system development 5.44e-03 5 5 1894 14467 ZIC1,SOX5,ALX3,ZIC3,GLI1
GO:0007224 smoothened signaling pathway 8.99e-03 2 5 37 14467 ZIC1,GLI1
GO:0048856 anatomical structure development 9.58e-03 5 5 2121 14467 ZIC1,SOX5,ALX3,ZIC3,GLI1
GO:0001501 skeletal development 1.02e-02 3 5 283 14467 ZIC1,SOX5,ALX3
GO:0007417 central nervous system development 1.42e-02 3 5 316 14467 ZIC1,SOX5,GLI1
GO:0045944 positive regulation of transcription from RNA polymerase II promoter 1.45e-02 3 5 318 14467 SOX5,ZIC3,GLI1
GO:0007275 multicellular organismal development 1.80e-02 5 5 2406 14467 ZIC1,SOX5,ALX3,ZIC3,GLI1
GO:0045893 positive regulation of transcription, DNA-dependent 1.97e-02 3 5 353 14467 SOX5,ZIC3,GLI1
GO:0051254 positive regulation of RNA metabolic process 1.99e-02 3 5 354 14467 SOX5,ZIC3,GLI1
GO:0045941 positive regulation of transcription 2.75e-02 3 5 395 14467 SOX5,ZIC3,GLI1
GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.17e-02 3 5 414 14467 SOX5,ZIC3,GLI1		 GO:0008589 regulation of smoothened signaling pathway 3.79e-04 2 5 12 21198 GLI1,ZIC1
GO:0007389 pattern specification process 8.74e-04 3 5 188 21198 ZIC3,GLI1,ZIC1
GO:0007224 smoothened signaling pathway 1.32e-03 2 5 22 21198 GLI1,ZIC1
GO:0009887 organ morphogenesis 1.60e-02 3 5 497 21198 ZIC3,GLI1,ZIC1
GO:0006366 transcription from RNA polymerase II promoter 4.74e-02 3 5 718 21198 SOX5,ZIC3,GLI1